Publications

Airway macrophage specific glycocalyx expression and remodeling following viral infection

Zhang Z., Nabi I.Z., Dalgarno S., Davies-Strickleton H., Akbulut I., Hussell T., Dyer D.P.

Matrix Biology 147, 102033 → DOI

A high-throughput SPR-based array for quantitative profiling of glycosaminoglycan–protein interactions

Birchenough H.L., Popplewell J.F., Dyer D., Day A.J., Jowitt T.A.

openRxiv Preprint → DOI

Label-free GAG disaccharide analysis by HILIC-MS/MS for studying diverse biological sample types

Davies-Strickleton H., Taylor G., Allsey J., Dalgarno S., Priestley M.J., Miller R.L., Knight D., Dyer D.P.

openRxiv Preprint → DOI

Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation

Priestley M.J., Hains A.K., Mulholland I.Z., Spijkers-Shaw S., Müller J.C., Ridley A.J.L., Davies-Strickleton H., Miller R.L., Dyer D.P. et al.

Science Signaling 18, eadr0011 → DOI

Heparan sulfate glycosaminoglycans mediate CXCL4 (PF4) transport across the blood-brain barrier and effects on neurogenesis

Weaver R.R., Gray A.L., Mateus-Gomes S., Ridley A.J., Birchenough H.L., Peterson F.C., Mulholland I.Z., Lowe K.O., Dyer D.P. et al.

Preprint — re-submitted to Science Signaling Preprint → DOI

Hallmarks and metabolic regulation of type 2 activated human lung macrophages

Ridley A.J.L., Curle A.J., Colombo S.A.P., Hughes J.J., Dyer D.P., MacDonald A.S. et al.

openRxiv Preprint → DOI

CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity

Pun N., Cytlak U.M., Lee D., Domingues R.G., Dyer D.P. et al.

Mucosal Immunology → DOI

Chemokine oligomers and the impact of fondaparinux binding

Szekeres G.P., Dyer D.P., Miller R.L., Pagel K.

Journal of the American Society for Mass Spectrometry 35(7), 1550–1555 → DOI

A systematic review of normal tissue neurovascular unit damage following brain irradiation

Nakkazi A., Forster D., Whitfield G.A., Dyer D.P., Dickie B.R.

Neuro-Oncology Advances 6(1) → DOI

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors

Gray A.L., Karlsson R., Roberts A.R.E., Ridley A.J.L., Pun N., Khan B., Dyer D.P. et al.

Cell Reports 42, 111930 → DOI

Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans

Ridley A.J.L., Ou Y., Karlsson R., Pun N., Birchenough H.L., Mulholland I.Z., Miller R.L., Dyer D.P.

Science Signaling 16, eadf2537 → DOI

The extracellular matrix and the immune system: a mutually dependent relationship

Sutherland T.E., Dyer D.P., Allen J.E.

Science 379 → DOI

CXCL17 binds efficaciously to glycosaminoglycans with the potential to modulate chemokine signalling

Giblin S.P., Ranawana S., Birchenough H.L., Dyer D., Pease J.E. et al.

Frontiers in Immunology 14 → DOI

Chronic cranial window implantation for high-resolution intravital imaging of the endothelial glycocalyx in mouse cortex

Gray A., Schiessl I., Dyer D.

STAR Protocols → DOI

Chemokine redundancy versus specificity in the context of CXCR3 and its ligands

Ridley A.J.L., Dyer D.

Immunology and Cell Biology 100(6), 387–389 → DOI

Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

Medina-Ruiz L., Bartolini R., Wilson G.J., Dyer D.P. et al.

eLife 11 → DOI

Role of extracellular matrix proteoglycans in immune cell recruitment

Gray A.L., Pun N., Ridley A.J.L., Dyer D.P.

International Journal of Experimental Pathology 103(2), 34–43 → DOI

Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates

Karlsson R., Chopra P., Dyer D.P., Miller R.L. et al.

Science Advances 7, eabl6026 → DOI

Immunomodulation by radiotherapy in tumour control and normal tissue toxicity

Cytlak U.M., Dyer D.P., Honeychurch J., Williams K.J., Travis M.A., Illidge T.M.

Nature Reviews Immunology → DOI

Understanding the mechanisms that facilitate specificity, not redundancy, of chemokine-mediated leukocyte recruitment

Dyer D.P.

Immunology → DOI

Perspectives on the biological role of chemokine:glycosaminoglycan interactions

Handel T.M., Dyer D.P.

Journal of Histochemistry and Cytochemistry → DOI

Chemokine receptor redundancy and specificity are context dependent

Dyer D.P., Medina-Ruiz L., Bartolini R., Graham G.J. et al.

Immunity 50(2), 378–389 → DOI

Kinetics of CXCL12 binding to atypical chemokine receptor 3 reveal a role for the receptor N terminus in chemokine binding

Gustavsson M., Dyer D.P., Zhao C., Handel T.M.

Science Signaling 12(598) → DOI

The chemokine receptor CXCR2 contributes to murine adipocyte development

Dyer D.P., Nebot J.B., Kelly C.J., Medina-Ruiz L., Graham G.J.

Journal of Leukocyte Biology → DOI

Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization

Dyer D.P., Migliorini E., Salanga C.L., Thakar D., Handel T.M., Richter R.P.

Open Biology 7, 160286 → DOI

CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses

Dyer D.P., Pallas K., Medina-Ruiz L., Wilson G.J., Graham G.J.

Scientific Reports 7, 42681 → DOI

The anti-inflammatory protein TSG-6 regulates chemokine function by inhibiting chemokine:glycosaminoglycan interactions

Dyer D.P., Salanga C.L., Johns S.C., Milner C.M., Day A.J., Handel T.M.

Journal of Biological Chemistry → DOI

The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization

Dyer D.P., Salanga C.L., Volkman B.F., Kawamura T., Handel T.M.

Glycobiology 26(3), 312–326

Cytokines and growth factors cross-link heparan sulfate

Migliorini E., Thakar D., Dyer D.P., Richter R.P. et al.

Open Biology 5(8)

TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8

Dyer D.P., Thomson J.M., Hermant A., Handel T.M., Proudfoot A.E.I., Day A.J., Milner C.M.

Journal of Immunology 192(5), 2177–2185

Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7

Salanga C.L., Dyer D.P., Chance M.R., Handel T.M.

Journal of Biological Chemistry 289(21), 14896–14912

Identification of the pharmacophore of the CC chemokine-binding proteins Evasin-1 and -4 using phage display

Bonvin P., Dunn S.M., Dyer D.P., Handel T.M., Proudfoot A.E.I.

Journal of Biological Chemistry 289(46), 31846–31855

A refined model for the TSG-6 Link module in complex with hyaluronan

Higman V.A., Briggs D.C., Dyer D.P., Day A.J., Milner C.M. et al.

Journal of Biological Chemistry 289(9), 5619–5634